#D-110 AAD 2024 - June 2025

Systemic Therapy for Hidradenitis Suppurativa: Real-World Outcomes

Dr. Benjamin Wright, Dr. Catherine Moore, Dr. Jason Taylor, Dr. Michelle Harris
Therapeutic Area: Dermatology
Company: Merck
Study Type: Observational Study

Key Findings

Biologic therapy achieved 63% HiSCR response at 16 weeks in real-world setting. Quality of life improved significantly.

Summary

Biologic therapy achieved 63% HiSCR response at 16 weeks in real-world setting. Quality of life improved significantly.

Study Design

Multicenter registry analysis of 850 patients with moderate-to-severe hidradenitis suppurativa receiving biologics.

Methods

Patients treated with TNF-alpha or IL-17 inhibitors. Outcomes: HiSCR, pain scores, quality of life, adverse events.

Results

HiSCR at 16 weeks: 63%. Pain NRS reduction: 42%. DLQI improved 58%. Treatment persistence: 78% at 1 year.

Conclusions

Biologic therapy effective for hidradenitis suppurativa in real-world practice with sustained benefits and good retention.

Full Abstract

This study examined systemic therapy for hidradenitis suppurativa: real-world outcomes in a comprehensive clinical investigation.